General Cell Based Assays
Cayman Chemical Prostaglandin D2-MOX Express
A Pim-3 kinase inhibitor (IC50 0.05 UM) selective for Pim-3 over Pim-1 and Pim-2 (IC50s 2.5 UM for both) inhibits the growth of DU145 and MIA PaCa-2 cells (IC50s 0.9 and 3.9 UM respectively) inhibits IL-6-induced STAT3 phosphorylation in DU145 cells at 10 UM
Montana Molecular TMPRSS2 BacMam - 30mL
TMPRSS2 packaged in BacMam for expression in mammalian cells. BacMam provides even, near 100% transduction efficiency in HEK293 cells as well as expression in many other cell lines, iPSCs, and primary cultures including A549s and HUVECs. Expression is easily titrateable to your experimental needs or to adjust assay sensitivity. This kit includes the TMPRSS2 BacMam and 500mM sodium butyrate in H2O. Use with other Montana Molecular tools including Pseudo-SARS-CoV-2 and BacMam-packaged ACE2, Neuropilin-1, and Cathepsin-L.
Cayman Chemical NBD-Fructose 5mg
A fluorescent derivative of fructose; has been used to monitor fructose uptake by the GLUT5 transporter in MCF-7, MDA-MB-435, and MDA-MB-231 human breast cancer cells; ex/em = 472/538 nm, respectively
Cayman Chemical Cel-Based asy nxIn V BI 50mL
A TRPV4 and TRPA1 inhibitor (IC50s 4.19 and 5.56 respectively for the rat channels) inhibits GSK1016790A-induced calcium influx in whole-cell patch-clamp assays using Neuro2a cells expressing TRPV4 at 5 UM prevents compression-induced increases in NF-KB transcriptional activity and secreted levels of IL-6 and VEGFA as well as inhibits compression-induced fractures abnormal cell morphology and fissures in the intervertebral space in primary mouse lumbar spines at 10 UM
Cell Signaling Technology Cyclic GMP XP Chemiluminescent Assay Kit 1 Kit
Cyclic GMP XP Chemiluminescent Assay Kit 1 Kit
Cayman Chemical TGR5GP-BAR1 Reporter asy 1ea
An IRE1a inhibitor (IC50s 0.2 and 0.02 UM for RNase and kinase activity respectively) selective for IRE1a over Ron and FGFR1 (IC50s 4.4 and 17 UM) as well as a panel of 282 kinases at 10 UM inhibits ER stress-induced increases in the splicing of mRNA encoding XBP1 in eight multiple myeloma cell lines at 8 UM reduces viral replication in tick-borne encephalitis virus-infected SH-SY5Y and SNB-19 cells at 0.5 UM and tick-borne encephalitis virus-infected Caco-2 cells at 1 UM
Meso Scale Discovery HUMAN TNF-RI ASSAY, 5 POINT, Electrochemiluminescence (ECL) Immunoassay, 96-well plate, Dynamic range 0.15 - 1,000 pg/mL, LLOD 0.15 pg/mL
HUMAN TNF-RI ASSAY, 5 POINT, Electrochemiluminescence (ECL) Immunoassay, 96-well plate, Dynamic range 0.15 - 1,000 pg/mL, LLOD 0.15 pg/mL
Cayman Chemical RXR RetInoId X receptr100uL
An inhibitor of PI3K and PI3KY (IC50s 24.5 and 33.2 nM respectively) greater than 300- and 120-fold selective for PI3K and PI3KY respectively over PI3Ka and PI3KB induces cell death in L-540 KM-H2 and L-428 cells at 10 UM induces cell cycle arrest at the G0/G1 phase in the same cells reduces tumor growth and vasculature induces tumor necrosis and induces the M1 phenotype in TAMs in an L-540 mouse xenograft model
Molecular Devices Cell Integrity Kit, Fluorescent, Live/Dead, 96- and 384-Well
The Molecular Devices EarlyTox Cell Integrity Kit R8214 is a fluorescence-based assay for rapid differentiation of live and dead cells using complementary nuclear dyes. The bulk kit is formulated for high-throughput imaging in 96- and 384-well plates and supports a homogeneous mix-and-read workflow with an optional masking reagent for improved signal.
- Sufficient for ten 96-well plates (approximately 960 wells) or equivalent 384-well plates.
- Contains two nuclear dyes for live and dead cell discrimination and masking reagent for homogeneous assays.
- Assay principle based on membrane permeability detection for live/dead identification.
- Compatible with adherent and non-adherent cell types and high-throughput imaging workflows.
- Recommended plate types: black-well, clear-bottom plates for imaging.
ABclonal Technology Somatostatin Receptor 2 SSTR2
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney